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Image biomarker standardisation initiative
The image biomarker standardisation initiative (IBSI) is an independent international collaboration which works towards standardising the extraction of image biomarkers from acquired imagingfor the purpose of high-throughput quantitative image analysis (radiomics). Lack of reproducibility and validation of high-throughput quantitative image analysis studies is considered to be amajor challenge for the ﬁeld 31,38,84 . Part of this challenge lies in the scantiness of consensus-basedguidelines and deﬁnitions for the process of translating acquired imaging into high-throughputimage biomarkers. The IBSI therefore seeks to provide image biomarker nomenclature and deﬁnitions, benchmark data sets, and benchmark values to verify image processing and image biomarkercalculations, as well as reporting guidelines, for high-throughput image analysis.